Abstract: OBJECTIVE To improve the physicochemical property of edaravone by inclusion technology. METHODS The inclusion constant of edaravone and cyclodextrin was determined by spectroscopic methodology and the inclusion complexes were prepared by levigation and solution method, characterized by the thermal analysis (DTA and TGA) methods, nuclear magnetic resonance method (1H-NMR) and X-ray diffractometry (XRD) techniques. The solubility and stability of edaravone were also measured. RESULTS Edaravone formed an optimal inclusion complex with cyclodextrin with the equilibrium constant of 146-4 285 L·mol ^-1. The inclusion complex increased the solubility and improved the stability of edaravone. CONCLUSION The solubility and stability of edaravone were significantly improved with cyclodextrin and this technique may have medical values for the development of edaravone preparation.