Abstract: OBJECTIVE To probe into the characteristics and regularity of adverse drug reaction (ADR) of Chinese patent medicines occurred in our hospital. METHODS A total of 118 ADR cases of Chinese patent medicines reported by clinical departments from Jan 2006 to Dec 2008 were classified and analyzed. RESULTS Patients aged from 41 to 80 were likely to have ADR. 86.44% of the ADR cases of Chinese patent medicines were induced by oral medication administration. Topping the list in terms of the incidence of ADR of Chinese patent medicines in descending order were antipyretic agent (21.67%), dampness-dispelling formula (15.83%) and blood-stasis-removing formula (15.00%). The ADR manifested mainly as lesions of skin and its appendants (36.76%), damage of digestive system (31.62%) and damage of nervous system (18.38%) etc. Thirty-two patients had severe adverse reactions (accounted 27.12%). All symptoms disappeared or relieved after drugs withdrawal or change to other drugs or treatment, no patients died. CONCLUSION It should be promoted to use Chinese patent medicines reasonably. To strengthen the monitoring, reporting, diagnosis and treatment of ADR of Chinese patent medicines is of utmost importance.