Abstract: OBJECTIVE To study the correlation between the drip rate of amifostine and the degree of nausea, the protection of bone marrow. METHODS There were 35 patients who were divided into group A and group B randomly, all of them received two periods of chemotherapies. In period I (control period), the patients were administrated with amifostine in 15 minutes before chemotherapeutics, however, the time was regulated in 60 minutes in prerion II(experimental period). The degree of nausea and toxicity of bone marrow were estimated after two periods. RESULTS Incidence rate of nausea in period I highly exceeded than period II for patients both in group A and B (P<0.01), but there was no obvious difference of the toxicity of bone marrow for patients between group A and B in period I and II. CONCLUSION There is no evidence showed that drip rate of amifostine was correlated to protection of bone marrow, whatever, to prolong the time of amifostine is thought to reduce the incidence rate of nausea.