Abstract: OBJECTIVE To study the protective effect of Jiangbai tablet, a Chinese medicine compound composed of Alpinta Officinarum, Cyperus Rotundus, Bulbus Lilii and Rlindera Strychnifolia, on the acetic acid-induced chronic gastric ulcer model in rats. METHODS　Chronic gastric ulcer was induced in rats with acetic acid. Jiangbai tablet or positive drug ranitidine were orally administered once a day after the surgery. Ten days later the rats were killed and the ulcer area was determined from the formula S=πLH/4 where L was the major axis and H was the minor axis of the site of ulcer, then both the content of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) in the gastric lesions were determined with the immune kits. RESULTS　Contrasting with the control group, Jiangbai tablet can significantly reduce the ulcer area (2.28±0.15, 1.66±0.49, 1.77±0.78 vs 7.18±2.03 mm2, P<0.05) and increase the content of the EGF(2.24±0.13, 1.93±0.16, 1.83±0.29 vs 1.66±0.33, P<0.05) and VEGF(2.28±0.15, 2.25±0.24, 2.27±0.29 vs 1.92±0.33, P<0.05) in gastric lesions. CONCLUSION Jiangbai tablet has antiulcer effects on acetic acid rat gastric ulcer model. The antiulcer mechanism may have some relationship with enhancing the production of EGF and VEGF in the gastric tissues.