Abstract: OBJECTIVE To observe the effect of various kinds of hypotensors on left ventricular remodeling and function in maintenance hemodialysis (MHD) patients. METHODS Eighty-seven MHD patients were randomly divided into four groups: CCB group (amlodipine, n=20), CCB combination with β-receptor blocker group (CCB+β-RB group, n=22), CCB combination with angiotensin-converting enzyme inhibitor group (CCB+ACEI group, n=23) and CCB combination with angiotensin receptor blockers group (CCB+ARB group, n=22). They were treated for 12 months. The left atrial end-systolic diameter (LAD), left ventricular end-diastolic (LVEDD), end-systolic dimensions (LVEDS), interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT) and ejection fraction (EF) were evaluated, then calculating left ventricular mass index (LVM) and left ventricular mass index(LVMI) with ultrasonic cardiography at 0, 6, 12 month. RESULTS At 12 month, compared with the pre-treatment, LVM and LVMI in CCB+β-RB group, CCB+ACEI group and CCB+ARB group were decreased significantly. Moreever, LVM and LVMI in CCB+ACEI group and CCB+ARB group were less than those in CCB+β-RB group. Compared with the pre-treatment, LVEDD, LVDS, VST and LPVWT in CCB+ACEI group and CCB+ARB group were decreased significantly. CONCLUSION Amlodipine combination with ACEI and ARB was more effective to inhibit left ventricular remodeling than that combination with β-RB in MHD patients.