Abstract: OBJECTIVE To observe the effects of chloroprocaine used in clinical epidural analgesia for the elder who had accepted transurethral resection of the prostate (TURP). METHODS Eighty patients of 60-75-year-old were enrolled in the randomized and double-blind study. They were divided into A, B, C and D four groups (n=20). All patients accepted L_3-4 3% chloroprocaine epidural anesthesia. After they were undergo TURP, the patients remained the epidural catheter for continuous epidural chloroprocaine hydrochloride analgesia for 3 days according to different doses: A group: 0.9% NS; B group: 1% chloroprocaine; C group: 1.2% chloroprocaine and D group: 1.5% chloroprocaine. We monitored the blurred vision score (VAS score), modified Bromage score, the number of bladder spasms, respiratory and circulatory changes, central nervous system reactions, and degree of satisfaction for all the patients. RESULTS For the VAS score and frequency of bladder spasm, the means of A group were less than those in B, C, and D group with significant statistics difference (P<0.01), the means of B group was less than those in C and D groups, but no statistical difference. Though C and D groups had no difference in VAS score, but the number of bladder spasm of D group was less than C group. The Bromage score of four groups were 0 in postoperation-6h. Nearly 11 patients in A group had low satisfaction and could not tolerate, most patients with continuous epidural chloroprocaine hydrochloride analgesia had satisfied with the analgesic effect. All patients had no respiratory and circulatory changes and the adverse reaction in the central nervous system. CONCLUSION The chloroprocaine used in epidural analgesia after TURP for the elder had good analgesia effect and safty.