Abstract: OBJECTIVE To select the best extraction process of compound Gusuibujiegu tablet．METHODS The time of extract, amount of solvent, times of extract and raw material for medicine granularity were choosed as variable factors. Orthogonal design method L9 (34) was used．RESULTS The optimum extraction was to smach the mixed raw material and pass through 20 mesh sieve, then extract twice with 10 times as much water, 1 h for each time, 20 items have sieved, withdraws with 10 times of quantity water 2 times, each time 1 h. CONCLUSION This method is simple，accurate and controllable.