Abstract: OBJECTIVE To explore the effects of Xingnaozaizao capsules on the hemorheology of blood stasis and the cerebral ischemia rat models. METHODS The blood stasis rat models were induced by intramuscular injection of the dexamethasone, and the cerebral ischemia rat models were induced by bilateral common carotid artery ligation. The blood stasis model rats were divided into six groups, rats were fed with large, medium and small-dose Xingnaozaizao capsule suspension, Zhongfenghuichun tablet suspension and the same volume of saline (two groups), and the other set up a group of blank control group, administered one time per day, continuous administration for 11 d. At the end of the experiment, the two common carotid arteries were applied by ligation after anesthesia animals separated, completely blank group and one group of saline group were implemented by the sham-operated. And then, decapitated blood, heparin anticoagulation, measured whole blood viscosity, plasma viscosity, erythrocyte rigidity, erythrocyte aggregation index. RESULTS Compared with model group, large, medium and small-dose Xingnaozaizao capsule and Zhongfenghuichun group could significantly reduce WBV, significantly reduce low-shear whole blood viscosity reduction and low-shear whole blood viscosity. Middle dose Xingnaozaizao capsule can obviously decrease plasma viscosity. Xingnaozaizao capsule can significantly (obviously) reduce high-shear whole blood reduction viscosity, high shear whole blood viscosity, erythrocyte rigidity and erythrocyte aggregation index. CONCLUSION Xingnaozaizao capsule could significantly improve the hemorheology of the blood stasis and cerebral ischemia rat models.