Abstract: OBJECTIVE To investigate the preparation technique and the optimal formulation of compound paracetamol and zinc gluconate dispersed tablets. METHODS The formula of compound paracetamol and zinc gluconate dispersed tablets were optimized in terms of disintegration time by studying single factor and orthogonal design tests. RESULTS The products formulated with the optimum techniques met the quality specification of dispersed tablets. And they obviously dissolved faster than the common tablets. CONCLUSION This prescription and technology of compound paracetamol and zinc gluconate dispersed tablets are reasonable, effective and suitable for industrial production.