Abstract: OBJECTIVE To set up a method of extraction technique of medicine cruing cancer on colon-specific target dropping pill. METHODS Using alkali-soluble acid ways to extract rutin from flos sophorae immaturus, then using the acid hydrolysis to obtain quercetin. Using traditional ethanol reflux to extract total curcumin from turmeric, using the content of turmeric as the total target, to determine the optimum extraction process through the analysis of orthogonal table. RESULTS Quercetin extraction conditions are as follows: alkaline is pH 8~9, acidic conditions is pH 3~5, extracting rutin, then add 100 times volume of 2% sulfuric acid to hydrolyze 90 minutes. The optimum extraction process of turmeric extraction are as follows: using 85% ethanol extract reflux 3 times, each time is 1 hour. Extracting the part-eluting of chloroform on silica gel column to collect total curcumin. CONCLUSION The process is feasible and supplying reference for production of medicine cruing cancer on colon-specific target dropping pill.