Abstract: OBJECTIVE To investigate the antioxidative effect of Maiqi oral solution (MOS) on aging model rats induced by D-galactose. METHODS Aging rats model was established by administrating D-galactose intraperitoneally. Sixty rats were divided into 6 groups randomly as follows: normal control group, model group, Vit C group, and three different doses of MOS. The activity of SOD, GSH-Px and the level of MDA in blood serum were measured. RESULTS Compared with model group, MOS could significantly improve the activity of SOD and GSH-Px, and markelly decrease the concentration of MDA in blood serum. CONCLUSION MOS has antioxidative effect on aging rats induced by D-galactose.