Abstract: OBJECTIVE To investigate the effect of intensive lipid-lowering hyperlipidemia in patients with high-sensitivity c-reactive protein and carotid artery intima-media thickness (CIMT). METHODS 164 cases of hyperlipidemia were randomly divided into conventional treatment group 79 cases, 85 cases of intensive lipid-lowering group, were to atorvastatin 10 mg·d^-1 or 40 mg·d^-1. In the former drug use and 6 months after the determination of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG). Observe high sensitive C-reactive protein (hs-CRP) and CIMT. RESULTS The outcome of intensive lipid-lowering group, hs-CRP by the former administration (5.14±0.96)mg·L^-1, drug use fell to 6 months at the time of (1.58±0.25)mg·L^-1(P<0.05), than conventional treatment group (5.16±0.98)mg·L^-1 reduced (2.68±0.5)mg·L^-1 have a more significant effect. CIMT group of intensive lipid-lowering drugs by the former (1.54±0.17)mm, drug use fell to 6 months at the time of (1.41±0.21)mm (P<0.05), than the conventional treatment group (1.54±0.16)mm to (1.51±0.17)mm significant results. CONCLUSION Intensive lipid-lowering therapy method is more effective in reducing high-sensitivity C-reactive protein (hs-CRP), reducing CIMT.