Abstract: OBJECTIVE To optimize the extraction technology of Tianning drop pill. METHODS The L9(34) orthogonal design was adopted in the study. Take the content of gastrodin and ferulic acid and yield of extract as index, to optimize the following factors in the extraction technology: ethanol concentration, amount of solvent, extraction time and extraction frequency. RESULTS The optimized condition was taken 70% ethanol as solvent, the best amount was 10 times of stuff solution, refluxed for three times and 1 hour for each time. CONCLUSION The optimized extraction technology is reasonable and provides scientific basis for industrialize process.