3,4,5-三甲氧基苯乙酸合成工艺改进

Improvement of Synthesis Process for 3,4,5-Trimethoxyphenyl Acetic Acid

摘要: 目的合成3,4,5-三甲氧基苯乙酸并进行工艺改进。方法　以3,4,5-三甲氧基苯甲醛为起始原料，经硼氢化钾还原、氯化、氰化、水解“一锅”反应得到3,4,5-三甲氧基苯乙酸。结果　所得产物经核磁共振谱确证，总收率64.2%。结论改进后的工艺，操作简便，环境污染小，更适合工业化生产。

Abstract: OBJECTIVE To improve the synthesis process of 3,4,5-trimethoxyphenyl acetic acid. METHODS 3,4,5-methoxyphenyl acetic acid was synthesized from 3,4,5-trimethoxybenzaldehyde by reduction with KBH4 in water, followed by chlorination, cyanation and hydrolysis in one-pot. RESULTS The overall yield was 64.2%. The structure of 3,4,5-trimethoxyphenyl acetic acid was confirmed by 1H-NMR. CONCLUSION The synthetic process is practical and easy to be scaled up.