Abstract: OBJECTIVE To introduce the clinical applications of GLP-1 and its analogues in type 2 diabetes. METHODS The latest research reports on the structural property and physiological functions of GLP-1 were summarized, as well as the clinical research and recent progress of clinically used GLP-1 analogues (Exendin-4 and Liraglutide, etc). Obstacles associated with their clinical usages and the remedy modification approaches were also described. RESULTS AND CONCLUTION Compared with the other clinical medicines, GLP-1 and its analogues have been proven to have greater therapeutic potential in treating type 2 diabetes.