Abstract: OBJECTIVE A meta analysis was performed to decide whether ampicillin, cefoperazone or piperacillin in combination with sulbactam is better to cure imipenem resistant Acinetobacter baumannii in China. METHODS After a comprehensive electronic and manual searching according to our strict criterions, the related data were used for subsequent meta analysis using RevMan 4.2. RESULTS Total 9 papers were collected. The resistant rate of IRAB versus ampicillin/sulbactam (62.8%) was significantly higher than that of cefoperazone/sulbactam (44.7%) (P<0.001), and the resistant rate of IRAB versus ampicillin/sulbactam (70.7%) was significantly lower than that of piperacillin/sulbactam (95.2%) (P<0.001). That is to say, among the three sulbactam complex the resistant rate of IRAB versus cefoperazone/sulbactam was the highest, while the resistant rate of IRAB versus piperacillin /sulbactam was the lowest.CONCLUSION In the process of curing IRAB infections, cefoperazone/sulbactam is more sensitive than ampicillin/sulbactam and piperacillin/sulbactam, and thus is a better candidated antibiotic.