Abstract: OBJECTIVE To study drug-loading and coating process of glipizide sustained-release pellets by fluidized bed apparatus instead of by centrifugal type coating-granulating machine. METHODS Comparing drug-loaded rate, the release rate in-vitro and work efficiency of the two different kinds of process technology, the orhogonal design was used to optimize the manufacturing process, without any change of its prescription components. RESULTS The pellets produced by fluidized bed apparatus were coincident with the quality standard. Its work efficiency was improved and meanwhile its labor and energy consumption were lower than before. CONCLUSION The new process of preparing the pellets is better than the old one, and it is feasible to be applied to manufacture.