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    蛞蝓胶囊致畸和致突变实验研究

    Study of Slug Capsule on Teratogenicity and Mutagenicity

      摘要
    • 摘要: 目的 探讨蛞蝓胶囊是否具有致畸和致突变的毒理作用。方法 本研究采用大鼠致畸胎、艾姆斯(Ames)试验、小鼠骨髓细胞微核试验、体外细胞染色体畸变试验检测的蛞蝓胶囊致畸胎、致突变性。结果 蛞蝓胶囊各剂量对孕鼠体重、胚胎早期发育、胚胎生长发育、以及胎鼠的骨骼发育和内脏器官发育等均无不良影响。无论加与不加S9，各剂量组诱变TA98、TA100种菌落数均未超过自然回变菌落数，与阴性对照组比较均无显著性差异(P>0.05)。与对照组相比，各剂量组对小鼠的微核率无明显的影响(P>0.05)。蛞蝓胶囊对培养的哺乳动物体细胞染色体结构无致畸变作用。结论 蛞蝓胶囊各剂量均无致畸和致突变的作用，说明在临床应用剂量范围内是安全的。

       

      Abstract: OBJECTIVE To explore the toxicological effects of Slug capsule on teratogenicity and mutagenicity. METHODS Effects of Slug capsule on teratogenicity and mutagenicity weretested by teratogenesis in rats, Ames assay, Amblem nuclear test in bone marrow cells of mice and chromosome aberration (CA) analysis in vitro.RESULTS The development toxicity was not observed in the development of embryos after treatment of Slug capsule. Compared with the control group, Slug capsules have no significant effect on mutagenesis to TA98, TA100 with or without S9 (P>0.05).The rate of CA in mice induced by Slug capsules had no significant difference compared with the control group (P>0.05).Slug capsules had no effect on the cultural mammal somatic chromosome.CONCLUSION Slug capsules had no effects of teratogenicity and chromosome damage, and indicated its clinical application was to be safe.

       

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