Abstract: OBJECTIVE Fangjiewan is a newly developed Chinese medicine. This is to study its Huoxuehuayu effects. METHODS The effects on hemorheology were observed in acute blood-stasis model rats，which were induced by swimming in ice water or being injected adrenalin. The effects on microcirculation were observed in mesenteric microcirculation disorder model rats induced by being injected adrenalin. And the blood clotting time were determined to evaluate the effects on PT and KPTT in rabbits. RESULTS Fangjiewan can significantly lower the animals' whole blood viscosity，plasma viscosity, blood fibrinogen concentration, ESR and platelet adhesion rate; can improve the hypercoagulable and high viscous state of blood so that avoid the appear of thrombosis; can make improvement in arterial narrowing, slow blood flow, reduction of open capillary and change of blood flow pattern; can extend the PT and KPTT time. CONCLUSION Fangjiewan has the effects on improving the hemorheology and microcirculation disorder, inhibiting either endogenous or extrinsic coagulation. The test results indicate that Fangjiewan has the Huoxuehuayu effects.