黄杨宁缓释胶囊释放度的研究

Study on Release Rate of Huangyangning Sustained-Release Capsules

摘要: 目的研究自制的黄杨宁缓释胶囊的体外释放度。方法采用酸性染料染色分光光度法测定黄杨宁缓释胶囊的释放度，0.05 mol·L-1的磷酸二氢钠缓冲溶液为释放介质，转速为100 r·min-1。结果平均回收率98.5%，RSD=3.39%，3批样品在1，4，8 h的平均累计释放度分别为23.10%，57.39%和85.86%，释放度符合要求。结论自制黄杨宁缓释胶囊有较好的释药性能。本试验建立的释放度测定方法可以作为该制剂的质控方法。

Abstract: OBJECTIVE To investigate the release rate of Huangyangning sustained-release capsules in vitro. METHODS Acidic dye spectrophotometry was used, with the release medium of 0.05 mol·L-1 sodium dihydrogen phosphate buffer solutions. The rotation speed was 100 r·min-1. RESULTS The average recovery was 98.5% (RSD=3.39%). The average cumulative releases for the three samples at 1 h, 4 h and 8 h were 23.10%, 57.39% and 85.86%, respectively. CONCLUSION The sustained-release capsules showed a favourable release property. The assay method of release rate in this paper could be used as quality control method.