Abstract: OBJECTIVE To observe the effect of Qushuanling capsule on the function of platelet aggregation in animals. METHODS The platelet aggregation was induced by adenosine diphosphate (ADP), thrombin and arachidonic acid (AA), and by this way we determined the changes of platelet aggregation in normal rats and acute blood stasis rabbits after administration of Qushuanling capsule. RESULTS After treatment with Qushuanling capsule for 7 days by 62.5-250 mg·kg-1, the rate of maximal platelet aggregation was inhibited by 13.8%-24.0% for ADP and 11.6%-35.3% for thrombin, and 22.1%-33.9% for ADP and 16.3%-23.6% for thrombin in 37.5-150 mg·kg-1-treated rabbits, respectively, but the drug had no effect on the AA-induced platelet aggregation. CONCLUSION Qushuanling capsule might obviously inhibit the ADP or thrombin mediated the platelet aggregation in rats and rabbits.