Abstract: Objective To evaluate the therapeutic effect of oxymatrine combined with highly active antiretroviral therapy (HAART) on the treatment of HIV/AIDS patients. Methods 57 HIV /AIDS patients were randomized into two groups, control group (n=21) and treatment group (n=36). The control group was treated with HAART, and treatment group was treated with oxymatrine in addition to HAART. The viral loads were determined before treatment and after treatment for 2 months and 6 months. CD4+T lymphocytes and serum IL-18 levels were detected before treatment and after treatment for 2 months, 4 months and 6 months. Results The viral loads were all decreased in two groups after treatment. There was no statistically significant difference between the two groups in 2 months after the treatment, but the significant differences were found 6 months after the treatment(P＜0.05). CD4+T cell counts increased in both groups after the treatment, while in treatment groups CD4+T cell counts were higher than those in control gronps in 2, 4 and 6 months after the treatment (P＜0.05). Serum IL-18 levels were decreased after the treatment in two groups, especially after treatment for 6 months, the significant difference being observed between two groups (P＜0.05). Conclusion Oxymatrine combined with HARRT could more effectively inhibit HIV reproductions, improve body’s immune function and abnormal cytokines levels than the single use of HARRT.