Abstract: OBJECTIVE To study the preparation of sinomenine gel and transdermal absorption of gel through rat skin．METHODS Cabapol was used as gel material to prepare sinomenine gel. The permeability of sinomenine through rat skin was evaluated by using the TK-12A type diffusion cells. RESULTS Cabapol showed it was a suitable material for gel preparation and had larger permeation flux, and the effect of 10% propanediol in absorption of sinomenine from cabapol gel through rat skin was not obvious. CONCLUSION Sonimenine-containing gel with cabapol is suitable for transdermal delivery of drug.