Abstract: OBJECTIVE To review the update of the study on polysaccharide micro-preparations. METHODS The review discussed the research of novel micro-preparations of polysaccharides in recent years at home and abroad，and the method of preparation, performance, effective function were also summarized. RESULTS The novel micro-preparation of polysaccharide can not only improve stability, bioavailability, and difficulty in penetration to some cells of polysaccharide，but also enhance the pharmacodynamic action and induce the targeting of polysaccharide drugs. CONCLUSION The novel micro-preparations of polysaccharides are promising, which can be used for effective cancer therapy.