Abstract: OBJECTIVE To observation the effect of the preparation of Ginkgo-biloba leaves in the coronary heart disease patients with blood glucose, serum insulin and lipids. METHODS The prospective, randomized controlled study was conducted in 78 selected patients with the coronary heart disease. They were randomly assigned to the treated group and control group. The course of treatment was 4 month. The blood glucose, serum insulin and lipids were observed. RESULTS After treatment, there was significant difference in the coronary heart disease patients with blood glucose, serum insulin and lipids (P<0.05). CONCLUSION The preparation of Ginkgo-biloba can significantly improve blood glucose, lipids and insulin resistance, the coronary heart disease patients can long-term use it.