Abstract: OBJECTIVE In order to study anti-inflammation mechanism of fungus garden of Odontotermes formosa-nus. METHODS Four types of models of the norml mouse and the excision two-sides adrenal gland mouse paw swollen induced by carrageenan, rat pleurisy induced by carrageenom,mouse paw swollen induced by allrumin were set up. The enzyme linked immunosorbent assay, the spectrophotometric and fluorometric method were used separately to measure the leukotriene (LTB4), the prostate gland (PGE2), hydroxy tryptamine (5-HT) and histamine level in the inflammatory percolate. RESULTS There was significant difference of PGE2, 5-HT, LTB4 or histamine between four types of models and the negative control group. CONCLUSION The anti-inflammation function of fungus garden of Odontotermes formosanus may be related to its suppression of PGB2, LTB4, 5-HT and histamine, and does not rely on hypothalamic-pituitary-adrenocortical system.