Abstract: OBJECTIVE To study the radical scavenging and anti-oxidation properties of microbial transformed curcumin by M.purureus went. METHODS A strain of M.purureus went was used for microbial transformation.The DPPH radical scav-enging ability of the transformed curcumin was studied,comparing to the ability of strain culture and substrate control.The anti-oxidation activity of the metabolites in hyperlipoidemia mices was assessed by the change of MDA, SOD, GSH-Px in liver and serum.The metabolites of curcumin extracted were separated and assayed by TLC and HPLC-DAD (Agilent Zorbax Extend C18 column，eluted by a gradient mixture of 0.1% acetic acid solution and acetonitric with flow rate of 1.0 mL·min-1). RESULTS The radical scavenging activity of curcumin was improved after being transformed.The transformed curcumin can reduce lipid perox-ides in hyperlipoidemia mices at dosage of 500, 200, 100 mg·kg·d-1 (Corresponding to curcumin 5, 2, 1 mg·kg·d-1) while strain culture control and substrate control seemed no effects. The transformed curcumin had no significant effect on the activity of the enzyme SOD and GSH-Px.Analysis of the metabolites showed that there were 6 me-tabolites, with retention times of 16.3, 22.1, 23.2, 28.0, 33.0, 36.1 min respectively.The spectra of these metabolites were all different but similar to that of curcumin. CONCLUSION Six metabolites of curcumin were transformed by M.purureus went and became a new combinatorial natural curcumoids group. The radical scavenging and anti-oxidation properties were improved.