Abstract: OBJECTIVE By Studying the interventional effect on antibiotics in our hospital, we try to evaluate the feasibility of rational application of antibiotics and promote its' rational use. METHODS To compare the indicators of the intervened group with the preintervened one. RESULTS After intervened, the average stay period and expense of hospitalization both got lower, expense of antibiotics, antibiotics kinds and the average used period of antibiotics decreased notably, and the ratio of infection had no significant difference. CONCLUSION Compositive intervention has improved the rational use of antibiotics. Moreover, it promotes to use of antibiotics safely, effectively and economicly.