Abstract: OBJECTIVE To establish the dissolution method for the three compositions of compound glycyrrhizin tablets. METHODS According to Ch.P (2005) dissolution method ΙΙ and using distilled water as the dissolution medium. The dissolution of compound glycyrrhizin tablet was determined by HPLC. The parameters(T50, Td, m)obtained from the dissolution tests were analysed. Degree of similarity of the dissolution was assessed using trial drugs and controlled drug. RESULTS There were no significant differences in dissolution parameters between trial drugs and controlled drugs(P>0.05). The dissolution of the three compositions of trial drugs was similar to controlled drug. The similar factor was 81.3, 75.2 and 77.3, respectively. CONCLUSION The method is simple, accurate and well reproducible. It can be used as a reliable method for the quality control of compound glycyrrhizin tablets. The dissolution characters of trial drugs similar with controlled drugs. The results show that the technology of producting trial drugs was stable and reliable.