Abstract: OBJECTIVE To discuss the clinical curative effect and security of gestodene compound and gestodene-ethinylestradiol used to treat dysfunctional uterine bleeding (DUB) in peri-menopausal period. METHODS Eighty-six peri-menopausal DUB patients were randomly devided into two groups. Gestodene-compound(A) group and gestodene- ethinylestradiol(B) group consisted of 43 patients each.Patients in gestodene-compound group were given 1 tablet gestodene- compound per 12 hour in bleeding period,and continued to take in the same dose up to the 20th day after bleeding stopped, then took in 1 tablet of gestodene-compound per day since the fifth day of menstrual period for 21days.And the second group patients were given gestodene-ethinylestradiol in the same way of the gestodene-compound group. RESULTS Both of two groups stopped bleeding within 72 hours after medication.And there was no break-through bleeding again during continuous medication. After the period of decrement A group had 2 patients(4.65%) while B group had 4 patients(9.30%) who had break-through bleeding.There was no significant difference between two groups(P>0.05). Besides these 6 patients, the rest patients were menstruation regular while taking medicine. There was no significant difference between two groups(P >0.05) of the side effect with no severe adverse effect.CONCLUSION Gestodene-compound and gestodene-ethinylestradiol are effective,safe drugs which are applicable for all types of DUB in peri-menopausal period. To keep taking in same dose through the treating period can avoid break-through bleeding with no rise of side effect.