Abstract: OBJECTIVE To explore the protective effects of Millettia nitida Benth.var.hirsutissima Z.Wei on hematopoietics system of sublethal dose 60Coγ-ray irradiated mice. METHODS White blood cell(WBC),red blood cell(RBC), hemoglobin (HGB) and platelet (PLT) counts in peripheral blood of sublethal dose 60Coγ-ray irradiated mice were detected 1,7,14,21 days,the spleen index and thymus index were compared 21 days after intragastion administration of different doses of Millettia nitida Benth.var.hirsutissima Z.Wei,successively. RESULTS A slowdown of the decrease of WBC,RBC,HGB and PLT counts in peripheral blood of the irradiated mice was observed after intragastric administration of Millettia nitida Benth.var.hirsutissima Z.Wei,spleen index and thymus index were higher than those of the model control group(P<0.05. CONCLUSION Millettia nitida Benth.var.hirsutissima Z.Wei can accelerate the recovery of WBC,RBC,HGB and PLT counts in peripheral blood and protect the hematopoietic system of the irradiated mice.