Abstract: OBJECTIVE To study on hypoglycemic effects of high frequency Chinese medicines(HFCMs) for diabetes. METHODS Twenty HFCMs for diabetes and their average dosage were collected by statistics. Their hypoglycemic effects, synergistic effects and dosage associations were observed on rat and mouse diabetic models induced by alloxan monohydrate. RESULTS Rhizoma Coptidis,Fructus Schisandrae,Radix Astragali, Radix Puerariae were more effective to lower the serum glucose levels of diabetic mouse models induced by alloxan monohydrate.There was no dosage association observed near the clinical dosage for Radix Astragali,Radix Puerariae.No synergistic effects to lower the serum glucose levels of diabetic rat model between Rhizoma Coptidis,Radix Astragali and Radix Puerariae were observed. CONCLUSION In the most frequently prescribed traditional Chinese medicines for diabetes,Rhizoma Coptidis,Fructus Schisandrae,Radix Astragali and Radix Puerariae are more effective to lower the serum glucose levels.