Abstract: OBJECTIVE This paper analyzes the occurrence situation incident about the adverse drug reactions (ADR) of anti-infection medicine which happened in our hospital in recent years, and give the reference for clinical security and the rational use of medicine. METHODS With the 159 ARD reports on anti-medicine that the ADR observation group collected from January 1999 to October 2007,this passage made the retrospective statistical analysis on these data. RESULTS159 ADR reports involves the 12 kinds of medicine which include 41 varieties. On the top of these is the quinolones, and the medicines like the lincomycin and the penicillin is the next. Clinical manifestation of ARD are mainly the harm of skin and its accessory, the secondary are digestive system′s and nervous system′s. CONCLUSIONWe should use the anti-infection medicine rationally, pay attention to the observation of ADR, and then avert the accident of ADR.