Abstract: OBJECTIVE To prepare Chinese Qingyan Spray and observe its clinic effects. METHODS Qingyan Spray was prepared through decoction, penetrability, lixiviation and its clinic effects were observed. RESULTS The number of obviously effective cases, efficient cases and inefficient cases of curative group was 22, 22 and 2, respectively. Overall efficiency was 95.86%. Compared with control group, the number was 5, 6 and 2, respectively and the overall efficiency was 86.67 %. CONCLUSION Qingyan Spray can cure chronic pharyngitis with reliable therapeutic efficacy and little toxic effect.