Abstract: OBJECTIVE To study the protective effect of resveratrol on experimental gastric mucosal lesion in mice.METHODS Make the model of gastric mucosal lesion in mice induced by ethanol absoute,aspirin and indomethacin.The area of gastric mucosal lesion in mice was determined.The contents of MDA and SOD of gastric tissue were measured.RESULTS The area of experimental gastric mucosal lesion in mice was inhibited after administration of resveratrol（25,50,100 mg·kg-1,ig）.The increase of MDA formation induced by aspirin was significantly decreased by resveratrol,and the decrease of SOD content of gastric mucosal tissue was elevated to normal level.CONCLUSION Resveratrol could possess protective effect on experimental gastric mucosal lesion in mice. Its mechanism may be related to antioxidative effect and improvement of SOD level to normal.