胰岛素肺部给药系统研究进展

Research and Development of Insulin Formulations for Pulmonary Delivery System

摘要: 目的介绍胰岛素肺部给药系统的研究进展。方法综述了肺部给药机制、胰岛素吸入制剂/装置、药动学和药效学特点、临床应用等研究内容。结果与结论胰岛素肺部给药系统的发展用以补充和/或替代皮下注射,可能是一种有效方法,使患者获得更好地糖尿病治疗结果。

Abstract: OBJECTIVE To introduce the research and development of insulin formulations for pulmonary delivery system.METHODS This review will discuss the mechanism of pulmonary delivery,inhaled insulin formulations/devices,pharmacokinetics and pharmacodynamics,the e