抗抑郁药盐酸度洛西汀的合成
Synthesis of Antidepressant Drug Duloxetine Hydrochloride
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摘要: 目的合成盐酸度洛西汀并改进合成工艺。方法以2-乙酰噻吩为起始原料,经Mannich反应、还原、拆分、醚化、脱甲基、成盐等反应制得盐酸度洛西汀。结果所得产物经元素分析、紫外光谱、红外光谱、核磁共振谱及质谱等确证了结构。结论此工艺路线方法简便,原料易得,便于工业化生产。Abstract: OBJECTIVE To synthesize duloxetine hydrochloride and optimize the process.METHODS Duloxetine hydrochloride was synthesized by steps of reaction(Mannich reaction,reduction,separation,etherication,demethylation and salification) from 2-acetylthiophene. RESU
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