N-三甲基壳聚糖对环孢素经皮渗透作用的试验研究
Study on the penetration effect of N-trimethyl chitosan on Cyclosporin
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Abstract: OBJECTIVE To study the penetration effect of N-trimethyl chitosan(TMC) on Cyclosporin.METHODS TMC60 was synthesized by a two-step method using chitosan and methyl-iodide.The degree of quaternization(DQ) of TMC was determined by 1H-NMR.The excised mice ski