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    洛铂的合成

    Synthesis of lobaplatin

      摘要
    • 摘要: 目的合成洛铂并进行工艺改进。方法以1,2-二氰基环丁烷为原料,经还原、缩合、环合三步反应得到洛铂。结果所得产物经熔点测定、元素分析确证其结构。结论采用此法合成洛铂是可行的,并合成工艺简单,易于工业化生产。

       

      Abstract: OBJECTIVE To synthesze lobaplatin and optimize the process.METHODS The compound was synthesize by steps of reduction,condensation and cyclic condensation from 1,2-dicyanocyclobutane. RESULTS Chemical structure of the product was confirmed by melting point

       

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