用不对称双羟化反应合成紫杉醇手性中间体(2R,3S)-2-3-二羟基-3-苯基丙酸乙酯
Preparation of ethyl(2R,3S)-dihydroxy-3-phenylpropinate as intermediate of taxoi by asymmetric dihydroxylation reaction
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Abstract: OBJECTIVE To synthesize a cheap ligand and determine it's catalytic activities in asymmetric dihydroxylation(AD)reaction and to get ethyl-(2R,3S)-dihydroxy-3-phenylpropionate with high yield and enantioselectivity.METHODS The new chiral ligand (QN)2PYDZ w