溴匹立明合成工艺的改进

Improve on the synthetic process of bropirimine

摘要: 目的合成溴匹立明并进行工艺改进。方法以乙酰乙酸乙酯为起始原料,经酰化、环合、溴化3步反应合成溴匹立明。结果所得产物化学结构经红外光谱、核磁共振氢谱及质谱确证,总收率为44.2%。结论改进的合成工艺简便、合理且可行。

Abstract: OBJECTIVE To synthesize bropirimine by improved method. METHODS Bropirimine was synthesized by 3 steps reaction of acylation, cyclization and bromination with ethyl acetoacetate as staring material. RESULTS Chemical structure of the product was confirmed