酮康唑脂质体凝胶剂的制备

The preparation of ketoconazole lipogel

摘要: 目的配制酮康唑脂质体凝胶剂，建立质量控制方法；方法采用薄膜法制备酮康唑脂质体，Sephadex G-50柱测定其包封率，利用高效液相法测定酮康唑脂质体凝胶剂中酮康唑的含量。结果脂质体凝胶剂为乳白色，脂质体平均包封率为65%。结论该脂质体凝胶剂制备工艺可行，检测方法可靠。

Abstract: OBJECTIVETo prepare ketoconazole lipogel and to establish the method of controlling qulity. METHODSThe ketoconazole lipogel was prepared by diaphragm method.The enveloping rate of ketoconazole liposome and qulity of lipogel was determined.by HPLC method