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    肿瘤血管生成抑制剂CA-4的合成

    Synthesis of tumour vascular inhibitor CA-4

      摘要
    • 摘要: 目的合成针对肿瘤血管的新一代高效低毒抗癌物质CA-4,并改进工艺。方法本文以廉价的异香兰素为起始原料,经过Wittig等六步反应合成CA-4。结果所得产物经IR和1HNMR确证。结论原料廉价,工艺易过渡于工业生产。

       

      Abstract: OBJECTIVE To provide a new process for preparing CA-4 used as an agnet for anti-tumour. METHOD The product was synthesized from inexpensive isovanillin by six-step reactions. RESULT The chemical structure of the product was determined by IR and 1HNMR. CON

       

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