3-(4-甲磺酰基)苯基-2-环己基-2-丁烯酸-γ-内酯的合成

Synthesis of 3-4-(methylsulfonyl)phenyl-2-cyclohexyl-2-crotonolactone

摘要: 目的　设计并合成了标题化合物。方法　以对甲磺酰基苯乙酮为原料,经溴代、缩合和环合三步反应合成了产物。结果　总收率为82.5%,中间体和产物经核磁共振谱和质谱确证。结论　成功地合成了设计的化合物,而且摸索了反应条件,使反应具有时间短,收率高等优点。

Abstract: OBJECTIVE To modify the structure of Rofecoxib(COX-2 inhibitor) and synthesize the title compound.METHOD The title compound was synthesized from p-methylsulfonyl-acetophenone via bromination ,condensation and cyclization.RESULTS The total yield amount