Ⅲ类抗心律失常药多非利特的合成
Synthesis of class Ⅲ antiarrhythmic agent Dofetilide
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Abstract: OBJECTIVE To synthesize dofetilide and optimize the process. METHOD Dofetilide was synthesized by steps of reaction (substitution ,reduction, methylsulfonylation and methylammoniation, etc) from p-nitrophenol and p-amino phenethyl alcohol. RESULTS Chem
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