N,N-双取代脲类克鲁斯氏锥体虫半胱氨酸蛋白酶小分子抑制剂的合成及其活性研究
Study on the synthesis and bioactivity of N,N-bis-substituted urea derivatives as novel small molecular inhibitors of cysteine protease of Tryponosoma cruzi
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Abstract: OBJECTIVE To search the small molecular inhibitors of cysteine protease of Tryponosoma cruzi.METHOD The N,N-bis-substituted urea was chosen as the lead scaffold based on the computational molecular modeling of cruzain. The target compounds were synthesi
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