奈非西坦(Nefiracetam)的合成

Synthesis of nefiracetam

摘要: 目的　合成脑功能改善药奈非西坦并改进合成工艺。方法　产物由2 ,6-二甲基苯胺酰化,然后与2-吡咯烷酮缩合而得。结果　所得产物结构经IR和1HNMR确证。结论　此法可行并易于过渡到工业生产。

Abstract: OBJECTIVE To provide a process for preparing nefiracetam used as an agent for improving cerebral function. METHOD The product was obtained by amidating 2,6-xylidine with chloroacety chloride and then condensing the resulting halogenoacetamide derivative