神经内肽酶抑制剂消旋卡多曲(Racecadotril)的合成工艺研究
Synthesis of antisecretory enkephalinase inhibitor racecadotril
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摘要: 目的合成神经内肽酶抑制剂消旋卡多曲。方法以氯苄为起始原料，经六步反应合成消旋卡多曲。结果每步反应均经改进，总收率为60%。所得产品经元素分析，IR,1HNMR,13CNMR光谱数据与文献报道一致。结论本工艺路线方法简单，原料易得，适合工业化生产。Abstract: OBJECTIVETo synthesize Racecadotril , a new drug for antisecretory enkephalinase inhibitor. METHODWith the benzyl chloride as the starting material, Racecadotril was synthesized via a six-step.RESULTSEach step was modified and improved ,the total yield w
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