复方戊酸雌二醇片的溶出度研究

Study on the Dissolution of Compound Estradiol Valerate Tablets

摘要: 目的　进行复方戊酸雌二醇片溶出度的方法学研究。方法　采用桨法,以0 .2 5 %十二烷基硫酸钠的磷酸盐缓冲液(pH7.3)为溶出介质,用高效液相色谱法测定溶出度。结果　本法的平均回收率高,产品的溶出度均一性好,与进口品溶出度曲线相近。结论　本法适用于该制剂的溶出度质量控制

Abstract: OBJECTIVE To study the dissolution methodology of compound estradiol valerate tablets. METHOD Using 0.25% sodium lauryl sulphate in phosphate buffer (pH=7.3) as medium and samples were determined by HPLC. RESULTS The percentage of EV and NET dissolved