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    大剂量顺铂化疗的药代动力学

    Pharmacokinetic Study of High Dose Cis-platin Chemotherapy

      摘要
    • 摘要: 目的:研究大剂量顺铂化疗的药动学。方法:用HPLC法测定血浆顺铂浓度。结果:血浆顺铂的药代动力学模式为开放二室模型,t1/2α为18.6 0 6min ,t1/2β为4 1.1782h。结论:大剂量顺铂化疗的t1/2β达4 1.1782h ,给药间隔须在三周以上

       

      Abstract: OBJECTIVE:Studied the pharmacokinetics of High Dose Cis-platin Chemotherapy. METHOD:The Platinum concentration was measured by HPLC.RESULTS:The results showed that the plasma clearance of platinum was biphasic. There was a short initial phase with a half

       

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